Highlights
Although the link between dietary intake and cancer has been studied for decades, the data on the anticancer effects of dietary interventions remain inconsistent.
Recent studies have demonstrated the powerful potential of particular diets in preventing tumorigenesis, delaying tumor growth, and improving the effectiveness of existing cancer treatments.
Understanding the interactions between cancer and diet is crucial for establishing diet as a line of treatment, and can uncover new mechanisms to target in the design of anticancer therapies.
Given the heterogeneous nature of cancer and host metabolism, several diets have been designed to target specific vulnerabilities.
The approach of precision nutrition aims to design diets tailored to each individual and their condition, with the goal of maximizing effectiveness while limiting adverse effects.
Abstract
In recent years dietary interventions have become a promising tool in cancer treatment and have demonstrated a powerful ability to alter metabolism and tumor growth, development, and therapeutic response.
However, because the mechanisms underlying dietary therapeutics are poorly understood, they are frequently ignored as a potential line of treatment for cancer.
We discuss the proposed mechanisms behind the anticancer effects of various diets and their development for clinical use.
This review aims to provide researchers and clinicians in the field of oncology with a complete overview of the contemporary landscape of nutritional interventions and precision nutrition as cancer therapeutics, and offers a perspective on the steps necessary to establish nutritional interventions as a standard line of treatment.
Authors: Carlos Martínez-Garay, Nabil Djouder.
Date: May 30, 2023
Link:
DOI: https://doi.org/10.1016/j.molmed.2023.04.004
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